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Arndt group publications


F. Küllmer, L. Gregor, H.-D. Arndt, "Tailoring of Asymmetric Azobenzenes for Photoswitching"

S. Schwarthoff, N. Tischer, H. Sager, B. Schätz, M. Rohrbach, I. Raztsou, D. Robaa, F. Gaube, H.-D. Arndt, T. Winckler, "Evaluation of γ-carboline-phenothiazine conjugates as simultaneous NMDA receptor blockers and cholinesterase inhibitors", in submission.

V. Nasufovic, F. Küllmer, J. Bößneck, H.-M. Dahse, H. Görls, P. Bellstedt, P. Stallforth, H.-D. Arndt, "Total synthesis and bioactivity mapping of geodiamolide H", Chem. Eur. J. 2021, provisionally accepted.

E. Molloy, M. Dell, V. Hänsch, K. L. Dunbar, R. Rietschel, A. Oberheide, L. Seyfarth, J. Kumpfmüller, T. Horch, H.-D. Arndt, C. Hertweck, "Enzyme-Primed Native Chemical Ligation Produces Autoinducing Cyclopeptides in Chlostridia", Angew. Chem. 2021, 60, 10670-10679.

S. Pospich, F. Küllmer, V. Nasufovic, J. Funk, A. Belvy, P. Bieling, H.-D. Arndt, S. Raunser, "Cryo-EM resolved molecular recognition of an optojasp photoswitch bound to actin filaments in both switch states", Angew. Chem. 2021, advance article.

V. Nasufovic, P. Then, F. Dröge, M. Duong, B. Dietzek, R. Heintzmann, H.-D. Arndt, "Si-Rhodamine isothiocyanate as a fluorescent labeling tool", Org. Biomol. Chem. 2021, 19, 574-578.

A. Oberheide, H.-D. Arndt, "Effective C5-arylation of peptide-integrated oxazoles: Almazole D", Adv. Synth. Catal. 2021, 363, 1132-1136


R. R. A. Freund, M. van den Borg, D. Gassmaier, R. Schlosser, T. Jacob, H.-D. Arndt, "Cornforth-Evans transition states in stereocontrolled allylborations of epoxy aldehydes", Chem. Eur J. 2020, 26, 8639-8650.

M. Borowiak, F. Küllmer, F. Gegenfurtner, S. Peil, V. Nasufovic, S. Zahler, O. Thorn-Seshold, D. Trauner, H.-D. Arndt, "Optical manipulation of F-actin with photoswitchable small molecules", J. Am. Chem. Soc. 2020, 142, 9240-9249 (press release of FSU Jena; featured on local radio SRB in German)

R. R. A. Freund, P. Gobrecht, D. Fischer, H.-D. Arndt, "Advances in parthenolide chemistry and biology", Nat. Prod. Rep. 2020, 37, 541-565.

M. Sauer, V. Nasufovic, H.-D. Arndt, I. Vilotijevic, "Robust Synthesis of NIR-emissive P-Rhodamine Fluorophores", Org. Biomol. Chem. 2020, 18, 1567-1571.


R. R. A. Freund, P. Gobrecht, P. Moser, D. Fischer, H.-D. Arndt, "Synthesis and biological profiling of parthenolide ether analogs", Org. Biomol. Chem. 2019, 17, 9703-9707.

A. Müller, S. Müller, V. Nasufovic, H.-D. Arndt, T. Pompe, "Actin stress fiber dynamics in laterally confined cells", Integr. Biol. 2019, 11, 175-185.

R. R. A. Freund, P. Gobrecht, Z. Rao, J. Gerstmeier, R. Schlosser, H. Görls, O. Werz, D. Fischer, H.-D. Arndt, "Stereoselective total synthesis of parthenolides indicates target selectivity for tubulin carboxypeptidase activity", Chem. Sci. 2019, 10, 7358-7364.

A. Oberheide, S. Schwenk, C. Ronco, L.-M. Semmrau, H. Görls, H.-D. Arndt, "Synthesis, Structures, and Cytotoxicity of Urukthapelstatin A Polyazole Cyclopeptide Analogs", Eur J. Org. Chem. 2019, 4320-4326 (cover feature: Eur J. Org. Chem. 2019, 4272).

S. Krieck, D. Kalden, A. Oberheide, L. Seyfarth, H.-D. Arndt, H. Görls, M. Westerhausen, "Synthesis and Catalytic Activity of Tridentate N-(2-Pyridylethyl)-Substituted Bulky Amidinates of Calcium and Strontium", Dalton Trans. 2019, 48, 2479-2490.

A. Oberheide, S. Pflanze, P. Stallforth, H.-D. Arndt, "Solid Phase Based Total Synthesis and Stereochemical Assignment of the Cryptic Natural Product Aurantizolicin", Org. Lett. 2019, 21, 729-732.


F. Merino, S. Pospich, J. Funk, F. Küllmer, H.-D. Arndt, P. Bieling, S. Raunser, "Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo EM", Nat. Struct. Mol Biol. 2018, 25, 528-537.

C. Rößler, H.-D. Arndt, "A master switch in thiopeptide biosynthesis", Cell Chem. Biol. 2018, 25, 121-123.


S. Zergiebel, H.-D. Arndt, A. Seeling, "Optimized Synthesis of new LE404-derived azecine-prodrugs", Tetrahedron Lett. 2017, 58, 3640-3642.

S. Zergiebel, C. Fleck, H.-D. Arndt, C. Enzensperger, A. Seeling, "Synthesis and Characterization of new Azecine-Derivatives as Potential Neuroleptics", Drug. Res. 2017, 67, 466-475.

K. B. Jadhav, C. Stein, O. Makarewicz, G. Pradel, R. J. Lichtenecker, H. Sack, S. H. Heinemann, H.-D. Arndt, "Bioactivity of topologically confined gramicidin A dimers", Bioorg. Med. Chem. 2017, 25, 261-268.


Y. Yonemura, X. Li, K. Müller, A. Krämer, P. Atigbire, T. Mentrup, T. Feuerhake, T. Kroll, O. Shomron, R. Nohl, H.-D. Arndt, C. Hoischen, P. Hemmerich, K. Hirschberg, C. Kaether, "Inhibition of cargo export at ER-exit sites and the trans-Golgi network by the secretion inhibitor FLI-06", J. Cell. Sci. 2016, 129, 3868-3877.

R. R. A. Freund, H.-D. Arndt, "Synthesis of (±)-4,5-dia-parthenolide, an unnatural parthenolide stereoisomer", J. Org. Chem. 2016, 81, 11009-11016.

L. Gelis, N. Jovancevic, S. Veitinger, B. Mandal, H.-D. Arndt, E. M. Neuhaus, H. Hatt, "Functional characterization of the odorant receptor 51E2 in human melanocytes", J. Biol. Chem. 2016, 291, 17772-17786

K. P. Wojtas, J.-Y. Lu, D. Krahn, H.-D. Arndt, "Regioselective functionalization of 3-hydroxypyridine carboxylates by neighboring group assistance", Chem. Asian J. 2016, 11, 2859-2862.

S. Schwenk, C. Ronco, A. Oberheide, H.-D. Arndt, "Biomimetic synthesis of urukthapelstatin A by Aza-Wittig ring contraction", Eur. J. Org. Chem. 2016, 4795-4799.

K. P. Wojtas, M. Riedrich, J.-Y. Lu, P. Winter, T. Winkler, S. Walter, H.-D. Arndt, "Total synthesis of nosiheptide", Angew. Chem. 2016, 128, 9924-9928; Angew. Chem. Int. Ed. 2016, 55, 9772-9776.


H. B. Bode, A. O. Brachmann, K. B. Jadhav, L. Seyfarth, C. Dauth, S. W. Fuchs, M. Kaiser, N. R. Waterfield, H. Sack, S. H. Heinemann, H.-D. Arndt, "Structure elucidation and activity of the giant-NRPS derived D-/L-pentadecapeptide kolossin A", Angew. Chem. 2015, 127, 10493-10496; Angew. Chem. Int. Ed. 2015, 54, 10352-10355; Highlighted in Nachr. Chem. 2015, 63, 974.

K. B. Jadhav, R. J. Lichtenecker, A. Bullach, B. Mandal, H.-D. Arndt, "Dynamic combinatorial enrichment of polyconformational D-/L-peptide dimers", Chem. Eur. J. 2015, 21, 5898-5908.

H.-D. Arndt, S. Rizzo, C. Nöcker, V. N. Wakchaure, L.-G. Milroy, V. Bieker, A. Calderon, T. T. N. Tran, S. Brand, L. Dehmelt, H. Waldmann, "Covalent divergent solid-phase synthesis of natural product-inspired bipartite cyclodepsipeptides - Total synthesis of seragamide A", Chem. Eur. J. 2015, 21, 5311-5316.


A. Wolf, S. Schoof, S. Baumann, H.-D. Arndt, K. N. Kirschner, "Structure-activity relationships of thiostrepton derivatives: Implications for rational drug design", J. Comput.-Aided Mol. Des. 2014, 28, 1205-1215.

G. Lukinavičius, L. Reymond, E. d'Este, A. Masharina, F. Göttfert, H. Ta, A. Güther, M. Fournier, S. Rizzo, H. Waldmann, C. Blaukopf, C. Sommer, D. W. Gerlich, H.-D. Arndt, S. W. Hell, K. Johnsson, "Fluorogenic probes for live-cell imaging of the cytoskeleton", Nat. Methods 2014, 11, 731-733.


R. J. Lichtenecker, B. Ellinger, H.-M. Han, K. B. Jadhav, S. Baumann, O. Makarewicz, M. Grabenbauer, H.-D. Arndt, "Iterative antimicrobial candidate selection from informed D-/L-peptide libraries", ChemBioChem 2013, 14, 2492-2499.

A. Krämer, T. Mentrup, B. Kleizen, E. Rivera-Milla, D. Reichenbach, C. Enzensperger, R. Nohl, E. Täuscher, H. Görls, A. Ploubidou, C. Englert, O. Werz, H.-D. Arndt, C. Käther, "Small molecules intercept Notch signaling and the early secretory pathway", Nat. Chem. Biol. 2013, 9, 731-738.

J.-Y. Lu, M. Riedrich, K. P. Wojtas, H.-D. Arndt, "Assembly of the nosiheptide A-ring: A fruitful lesson", Synthesis 2013, 1300-1311.

P. Loos, C. Ronco, M. Riedrich, H.-D. Arndt, "Unified Azoline and Azole Syntheses by Optimized Aza-Wittig Chemistry", Eur. J. Org. Chem. 2013, 3290-3315.


A. Wolf, S. Baumann, H.-D. Arndt, K. N. Kirschner, "Influence of thiostrepton binding on the ribosomal GTPase associated region characterized by molecular dynamics simulation", Bioorg. Med. Chem. 2012, 20, 7194-7205.

L.-G. Milroy, S. Rizzo, A. Calderon, B. Ellinger, S. Erdmann, J. Mondry, P. Verveer, P. Bastiaens, H. Waldmann, L. Dehmelt, H.-D. Arndt, "Selective chemical imaging of static actin in live cells", J. Am. Chem. Soc. 2012, 134, 8480-8486.

M. N. Aminake, H.-D. Arndt, G. Pradel, "The proteasome of malaria parasites: a multi-stage drug target for chemotherapeutic intervention?", Int. J. Parasitol. Drugs Drug Res. 2012, 2, 1-10.


L. Iovkova, D. Könning, B. Wängler, R. Schirrmacher, S. Schoof, H.-D. Arndt, K. Jurkschat, "SiFA-Modified Phenylalanine: A Key Compound for the Efficient Synthesis of 18F-Labelled Peptides", Eur. J. Inorg. Chem. 2011, 14, 2238-2246.

Y.-P. He, H. Tan, L. Arve, S. Baumann, H. Waldmann, H.-D. Arndt, "Biphenomycin B and Derivatives: Total Synthesis and Translation Inhibition", Chem. Asian J. 2011, 6, 1546-1556. 

S. Basu, B. Ellinger, S. Rizzo, C. Deraeve, M. Schürmann, H. Preut, H.-D. Arndt, H. Waldmann, "Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small molecule activator of the Wnt-pathway", Proc. Natl. Acad. Sci. USA 2011, 108, 6805-6810.

M. N. Aminake, S. Schoof, L. Sologub, M. Leubner, M. Kirschner, H.-D. Arndt, G. Pradel, "Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting the parasite proteasome and apicoplast", Antimicrob. Agents Chemother. 2011, 55, 1338-1348. 

H. R. A. Jonker, S. Baumann, A. Wolf, F. Hiller, S. Schoof, K. W. Schulte, K. N. Kirschner, H. Schwalbe, H.-D. Arndt, "NMR structures of thiostrepton derivatives reveal shape selective target recognition", Angew. Chem. 2011, 123, 3366-3370; Angew. Chem. Int. Ed. 2011, 50, 3308-3312.


S. Baumann, S. Schoof, M. Bolten, C. Haering, M. Takagi, K. Shin-ya, H.-D. Arndt, "Molecular determinants of microbial resistance to thiopeptide antibiotics", J. Am. Chem. Soc. 2010, 132, 6973-6981. 

C. P. R. Hackenberger, H.-D. Arndt, D. Schwarzer, "Semisynthese: Ein zentrales Werkzeug für die Chemische Biologie", Chem. Unserer Zeit 2010, 44, 198-206.

H.-D. Arndt, C. P. R. Hackenberger, D. Schwarzer, "Semisynthese: Chemie mit den Molekülen der Natur", Chem. Unserer Zeit 2010, 44, 130-137. 

S. Schoof, G. Pradel, M. N. Aminake, B. Ellinger, S. Baumann, M. Potowski, Y. Najajreh, M. Kirschner, H.-D. Arndt, "Anti-plasmodial thiostrepton derivatives are proteasome inhibitors with a dual mode of action", Angew. Chem. 2010, 122, 3389-3393; Angew. Chem. Int. Ed. 2010, 49, 3317-3321. 

R. Tannert, L.-G. Milroy, T.-S. Hu, B. Ellinger, S. Menninger, H.-D. Arndt, H. Waldmann, "Synthesis and structure-activity correlation of natural-product inspired cytotoxic cyclodepsi­peptides stabilizing actin", J. Am. Chem. Soc. 2010, 132, 3063-3077.


J.-Y. Lu, M. Riedrich, M. Mikyna, H.-D. Arndt, "Aza-Wittig-enabled synthesis of the nosiheptide A-Ring", Angew. Chem. 2009, 121, 8281-8284; Angew. Chem. Int. Ed. 2009, 48, 8137-8140.

S. Schoof, H.-D. Arndt, "D-Cysteine occurrence in thiostrepton may not necessitate an epimerase", Chem. Commun. 2009, 7113-7115.

H.-D. Arndt, S. Schoof, J.-Y. Lu, "Thiopeptide antibiotic biosynthesis", Angew. Chem. 2009, 121, 6900-6904; Angew. Chem. Int. Ed. 2009, 48, 6770-6773.

T. Walther, S. Renner, H. Waldmann, H.-D. Arndt, "Synthesis and structure-activity correlation of a brunsvicamide-inspired compound collection", ChemBioChem 2009, 10, 1153-1162.

P. Loos, M. Riedrich, H.-D. Arndt, "Aza-Wittig access to chiral imidazol(in)es", Chem. Commun. 2009, 1900-1902 ("Highlight" in: Synfacts 2009, 7, 728).

R. Tannert, T.-S. Hu, H.-D. Arndt, H. Waldmann, "Solid-phase based total synthesis of jasplakinolide by ring-closing metathesis", Chem. Commun. 2009, 1493-1495.

B. Kilitoglu, H.-D. Arndt, "Scope of Tyrosine O-Arylations with Boronic Acids: Optimized Synthesis of an Orthogonally Protected Isodityrosine", Synlett 2009, 720-723.

S. Schoof, S. Baumann, B. Ellinger, H.-D. Arndt, "A fluorescent probe for the 70S-ribosomal GTPase-associated center", ChemBioChem 2009, 10, 242-245.


H. Waldmann, Y.-P. He, H. Tan, L. Arve, H.-D. Arndt, "Total synthesis of biphenomycin B", Chem. Commun. 2008, 5562-5564. 

J.-Y. Lu, J. Keith, W.-Z. Shen, M. Schürmann, H. Preut, T. Jacob, H.-D. Arndt, "Regioselective de-novo synthesis of cyanohydroxy­pyridines with a concerted mechanism", J. Am. Chem. Soc. 2008, 130, 13219-13221. 

N. Bisek, S. Wetzel, H.-D. Arndt, H. Waldmann, "Synthesis and conformational analysis of stevastelin C3 analogs and their activity against the dual-specific phosphatase VHR", Chem. Eur. J. 2008, 14, 8847-8860. 

H. Waldmann, T.-S. Hu, S. Renner, S. Menninger, R. Tannert, T. Oda, H.-D. Arndt, "Total synthesis of chondramide C and its binding mode to F-actin", Angew. Chem. 2008, 120, 6573-6577; Angew. Chem. Int. Ed. 2008, 47, 6473-6477.

S. Baumann, S. Schoof, S. D. Harkal, H.-D. Arndt, "Mapping the binding site of thiopeptide antibiotics by proximity induced covalent capture (PICC)", J. Am. Chem. Soc. 2008, 130, 5664-5666.

T. Walther, H.-D. Arndt, H. Waldmann, "Solid-support based total synthesis and stereochemical correction of brunsvicamide A", Org. Lett. 2008, 10, 3199-3202. 

H.-D. Arndt, M. Riedrich, "Synthesis of marine alkaloids from the oroidin family", Angew. Chem. 2008, 120, 4864-4867; Angew. Chem. Int. Ed. 2008, 47, 4785-4788.

J.-Y. Lu, W.-Z. Shen, H. Preut, H.-D. Arndt, "(Z)-Methyl-2-(methoxyimino)-3-oxo-butyrate", Acta. Cryst. E 2008, 64, o602.


T.-S. Hu, R. Tannert, H.-D. Arndt, H. Waldmann, "Solid-phase based synthesis of jaspla­kinolide analogs by intramolecular azide/alkyne cycloadditions", Chem. Commun. 2007, 3942-3944.

R. Tannert, M. Schürmann, H. Preut, H.-D. Arndt, H. Waldmann, "(S)-3-((R)-2,4-dimethylpent-4-enoyl)-4-isopropyl-5,5-diphenyloxazolidin-2-one", Acta. Cryst. E 2007, 63, o4381.

H.-D. Arndt, S. Schoof, "Polyamide- and RNA-based activators in living cells: A major step towards controlling gene expression", ChemBioChem 2007, 8, 1095-1098.

J.-Y. Lu, H.-D. Arndt, "Hetero-Diels-Alder synthesis of 3-hydroxypyridines: Access to the nosiheptide core", J. Org. Chem. 2007, 72, 4205-4212.

M. Riedrich, S. D. Harkal, H.-D. Arndt, "Peptide-embedded heterocycles by mild single- and multiple aza-Wittig ring closures", Angew. Chem. 2007, 119, 2755-2758; Angew. Chem. Int. Ed. 2007, 46, 2701-2703.

R. L. Stafford, H.-D. Arndt, M. Brezinski, A. Ansari, P. B. Dervan, "Minimization of a DNA-protein dimerizer", J. Am. Chem. Soc. 2007, 129, 2660-2668. 

R. Wesolowski, A. Sommer, H.-D. Arndt, U. Koert, P. Reiß, S. Wimmers, O. Strauss, "Functional studies on synthetic gramicidin-hybrid ion channels in cells", ChemBioChem 2007, 8, 513-520.


H.-D. Arndt, "Small molecule modulators of transcription", Angew. Chem. 2006, 118, 4664-4673; Angew. Chem. Int. Ed. 2006, 45, 4552-4560.

Before 2006

K. E. Hauschild, R. E. Metzler, H.-D. Arndt, R. Moretti, M. Raffaelle, P. B. Dervan, A. Z. Ansari, "Temperature-sensitive protein-DNA dimerizers", Proc. Natl. Acad. Sci. USA 2005, 102, 5008-5013. 

Y. Kwon, H.-D. Arndt, Q. Mao, Y. Choi, Y. Kawazoe, P. B. Dervan, M. Uesugi, "A small molecule transcription factor mimic", J. Am. Chem. Soc. 2004, 126, 15940-15941.

H.-D. Arndt, B. Ziemer, U. Koert, "On the folding propensity of cyclohexylether-δ-peptides", Org. Lett. 2004, 6, 3269-3271. 

H.-D. Arndt, R. Welz, S. Müller, B. Ziemer, U. Koert, "Stereoselective synthesis of trans-threo-trans oligo-pyrrolidines: Potential RNA cleavage agents", Chem. Eur. J. 2004, 10, 3945-3962.

H.-D. Arndt, K. E. Hauschild, D. P. Sullivan, K. Lake, P. B. Dervan, A. Z. Ansari, "Toward artificial developmental regulators", J. Am. Chem. Soc. 2003, 125, 13322-13323.

H.-D. Arndt, D. Bockelmann, A. Knoll, S. Lamberth, C. Griesinger, U. Koert, "Cation control in functional helical programming: NMR-structures of a d-l-peptide ion channel", Angew. Chem. 2002, 114, 4234-4238; Angew. Chem. Int. Ed. 2002, 41, 4062-4065. 

H.-D. Arndt, A. Vescovi, A. Schrey, J. R. Pfeifer, U. Koert, "Solution phase synthesis and purification of the minigramicidin ion channels and a succinyl-linked gramicidin", Tetrahedron 2002, 58, 2789-2801. 

H.-D. Arndt, A. Knoll, U. Koert, "Cyclohexylether-δ-amino acids: New selec­tivity fil­ters in ion channels", Angew. Chem. 2001, 113, 2137-2140; Angew. Chem. Int. Ed. 2001, 40, 2076-2078.

H.-D. Arndt, A. Knoll, U. Koert, "Synthesis of minigramicidin ion channels and test of their hydrophobic match with the membrane", ChemBioChem 2001, 2, 221-223.

H.-D. Arndt, K. Polborn, U. Koert, "Stereoselective synthesis of a terpyrrolidine unit, a poten­tial building block for anion recognition", Tetrahedron Lett. 1997, 38, 3879-3882.