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Arndt group publications


A. Oberheide, S. Pflanze, P. Stallforth, H.-D. Arndt, "Solid Phase Based Total Synthesis and Stereochemical Assignment of the Cryptic Natural Product Aurantizolicin", Org. Lett. 2019, accepted for publication.


F. Merino, S. Pospich, J. Funk, F. Küllmer, H.-D. Arndt, P. Bieling, S. Raunser, "Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo EM", Nat. Struct. Mol Biol. 2018, 25, 528-537.

C. Rößler, H.-D. Arndt, "A master switch in thiopeptide biosynthesis", Cell Chem. Biol. 2018, 25, 121-123.


S. Zergiebel, H.-D. Arndt, A. Seeling, "Optimized Synthesis of new LE404-derived azecine-prodrugs", Tetrahedron Lett. 2017, 58, 3640-3642.

S. Zergiebel, C. Fleck, H.-D. Arndt, C. Enzensperger, A. Seeling, "Synthesis and Characterization of new Azecine-Derivatives as Potential Neuroleptics", Drug. Res. 2017, 67, 466-475.

K. B. Jadhav, C. Stein, O. Makarewicz, G. Pradel, R. J. Lichtenecker, H. Sack, S. H. Heinemann, H.-D. Arndt, "Bioactivity of topologically confined gramicidin A dimers", Bioorg. Med. Chem. 2017, 25, 261-268.


Y. Yonemura, X. Li, K. Müller, A. Krämer, P. Atigbire, T. Mentrup, T. Feuerhake, T. Kroll, O. Shomron, R. Nohl, H.-D. Arndt, C. Hoischen, P. Hemmerich, K. Hirschberg, C. Kaether, "Inhibition of cargo export at ER-exit sites and the trans-Golgi network by the secretion inhibitor FLI-06", J. Cell. Sci. 2016, 129, 3868-3877.

R. R. A. Freund, H.-D. Arndt, "Synthesis of (±)-4,5-dia-parthenolide, an unnatural parthenolide stereoisomer", J. Org. Chem. 2016, 81, 11009-11016.

L. Gelis, N. Jovancevic, S. Veitinger, B. Mandal, H.-D. Arndt, E. M. Neuhaus, H. Hatt, "Functional characterization of the odorant receptor 51E2 in human melanocytes", J. Biol. Chem. 2016, 291, 17772-17786

K. P. Wojtas, J.-Y. Lu, D. Krahn, H.-D. Arndt, "Regioselective functionalization of 3-hydroxypyridine carboxylates by neighboring group assistance", Chem. Asian J. 2016, 11, 2859-2862.

S. Schwenk, C. Ronco, A. Oberheide, H.-D. Arndt, "Biomimetic synthesis of urukthapelstatin A by Aza-Wittig ring contraction", Eur. J. Org. Chem. 2016, 4795-4799.

K. P. Wojtas, M. Riedrich, J.-Y. Lu, P. Winter, T. Winkler, S. Walter, H.-D. Arndt, "Total synthesis of nosiheptide", Angew. Chem. 2016, 128, 9924-9928; Angew. Chem. Int. Ed. 2016, 55, 9772-9776.


H. B. Bode, A. O. Brachmann, K. B. Jadhav, L. Seyfarth, C. Dauth, S. W. Fuchs, M. Kaiser, N. R. Waterfield, H. Sack, S. H. Heinemann, H.-D. Arndt, "Structure elucidation and activity of the giant-NRPS derived D-/L-pentadecapeptide kolossin A", Angew. Chem. 2015, 127, 10493-10496; Angew. Chem. Int. Ed. 2015, 54, 10352-10355.

K. B. Jadhav, R. J. Lichtenecker, A. Bullach, B. Mandal, H.-D. Arndt, "Dynamic combinatorial enrichment of polyconformational D-/L-peptide dimers", Chem. Eur. J. 2015, 21, 5898-5908.

H.-D. Arndt, S. Rizzo, C. Nöcker, V. N. Wakchaure, L.-G. Milroy, V. Bieker, A. Calderon, T. T. N. Tran, S. Brand, L. Dehmelt, H. Waldmann, "Covalent divergent solid-phase synthesis of natural product-inspired bipartite cyclodepsipeptides - Total synthesis of seragamide A", Chem. Eur. J. 2015, 21, 5311-5316.


A. Wolf, S. Schoof, S. Baumann, H.-D. Arndt, K. N. Kirschner, "Structure-activity relationships of thiostrepton derivatives: Implications for rational drug design", J. Comput.-Aided Mol. Des. 2014, 28, 1205-1215.

G. Lukinavičius, L. Reymond, E. d'Este, A. Masharina, F. Göttfert, H. Ta, A. Güther, M. Fournier, S. Rizzo, H. Waldmann, C. Blaukopf, C. Sommer, D. W. Gerlich, H.-D. Arndt, S. W. Hell, K. Johnsson, "Fluorogenic probes for live-cell imaging of the cytoskeleton", Nat. Methods 2014, 11, 731-733.


R. J. Lichtenecker, B. Ellinger, H.-M. Han, K. B. Jadhav, S. Baumann, O. Makarewicz, M. Grabenbauer, H.-D. Arndt, "Iterative antimicrobial candidate selection from informed D-/L-peptide libraries", ChemBioChem 2013, 14, 2492-2499.

A. Krämer, T. Mentrup, B. Kleizen, E. Rivera-Milla, D. Reichenbach, C. Enzensperger, R. Nohl, E. Täuscher, H. Görls, A. Ploubidou, C. Englert, O. Werz, H.-D. Arndt, C. Käther, "Small molecules intercept Notch signaling and the early secretory pathway", Nat. Chem. Biol. 2013, 9, 731-738.

J.-Y. Lu, M. Riedrich, K. P. Wojtas, H.-D. Arndt, "Assembly of the nosiheptide A-ring: A fruitful lesson", Synthesis 2013, 1300-1311.

P. Loos, C. Ronco, M. Riedrich, H.-D. Arndt, "Unified Azoline and Azole Syntheses by Optimized Aza-Wittig Chemistry", Eur. J. Org. Chem. 2013, 3290-3315.


A. Wolf, S. Baumann, H.-D. Arndt, K. N. Kirschner, "Influence of thiostrepton binding on the ribosomal GTPase associated region characterized by molecular dynamics simulation", Bioorg. Med. Chem. 2012, 20, 7194-7205.

L.-G. Milroy, S. Rizzo, A. Calderon, B. Ellinger, S. Erdmann, J. Mondry, P. Verveer, P. Bastiaens, H. Waldmann, L. Dehmelt, H.-D. Arndt, "Selective chemical imaging of static actin in live cells", J. Am. Chem. Soc. 2012, 134, 8480-8486.

M. N. Aminake, H.-D. Arndt, G. Pradel, "The proteasome of malaria parasites: a multi-stage drug target for chemotherapeutic intervention?", Int. J. Parasitol. Drugs Drug Res. 2012, 2, 1-10.


L. Iovkova, D. Könning, B. Wängler, R. Schirrmacher, S. Schoof, H.-D. Arndt, K. Jurkschat, "SiFA-Modified Phenylalanine: A Key Compound for the Efficient Synthesis of 18F-Labelled Peptides", Eur. J. Inorg. Chem. 2011, 14, 2238-2246.

Y.-P. He, H. Tan, L. Arve, S. Baumann, H. Waldmann, H.-D. Arndt, "Biphenomycin B and Derivatives: Total Synthesis and Translation Inhibition", Chem. Asian J. 2011, 6, 1546-1556. 

S. Basu, B. Ellinger, S. Rizzo, C. Deraeve, H.-D. Arndt, H. Waldmann, "Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small molecule activator of the Wnt-pathway", Proc. Natl. Acad. Sci. USA 2011, 108, 6805-6810.

M. N. Aminake, S. Schoof, L. Sologub, M. Leubner, M. Kirschner, H.-D. Arndt, G. Pradel, "Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting the parasite proteasome and apicoplast", Antimicrob. Agents Chemother. 2011, 55, 1338-1348. 

H. R. A. Jonker, S. Baumann, A. Wolf, F. Hiller, S. Schoof, K. W. Schulte, K. N. Kirschner, H. Schwalbe, H.-D. Arndt, "NMR structures of thiostrepton derivatives reveal shape selective target recognition", Angew. Chem. 2011, 123, 3366-3370; Angew. Chem. Int. Ed. 2011, 50, 3308-3312.


S. Baumann, S. Schoof, M. Bolten, C. Haering, M. Takagi, K. Shin-ya, H.-D. Arndt, "Molecular determinants of microbial resistance to thiopeptide antibiotics", J. Am. Chem. Soc. 2010, 132, 6973-6981. 

C. P. R. Hackenberger, H.-D. Arndt, D. Schwarzer, "Semisynthese: Ein zentrales Werkzeug für die Chemische Biologie", Chem. Unserer Zeit 2010, 44, 198-206.

H.-D. Arndt, C. P. R. Hackenberger, D. Schwarzer, "Semisynthese: Chemie mit den Molekülen der Natur", Chem. Unserer Zeit 2010, 44, 130-137. 

S. Schoof, G. Pradel, M. N. Aminake, B. Ellinger, S. Baumann, M. Potowski, Y. Najajreh, M. Kirschner, H.-D. Arndt, "Anti-plasmodial thiostrepton derivatives are proteasome inhibitors with a dual mode of action", Angew. Chem. 2010, 122, 3389-3393; Angew. Chem. Int. Ed. 2010, 49, 3317-3321. 

R. Tannert, L.-G. Milroy, T.-S. Hu, B. Ellinger, S. Menninger, H.-D. Arndt, H. Waldmann, "Synthesis and structure-activity correlation of natural-product inspired cytotoxic cyclodepsi­peptides stabilizing actin", J. Am. Chem. Soc. 2010, 132, 3063-3077.


J.-Y. Lu, M. Riedrich, M. Mikyna, H.-D. Arndt, "Aza-Wittig-enabled synthesis of the nosiheptide A-Ring", Angew. Chem. 2009, 121, 8281-8284; Angew. Chem. Int. Ed. 2009, 48, 8137-8140.

S. Schoof, H.-D. Arndt, "D-Cysteine occurrence in thiostrepton may not necessitate an epimerase", Chem. Commun. 2009, 7113-7115.

H.-D. Arndt, S. Schoof, J.-Y. Lu, "Thiopeptide antibiotic biosynthesis", Angew. Chem. 2009, 121, 6900-6904; Angew. Chem. Int. Ed. 2009, 48, 6770-6773.

T. Walther, S. Renner, H. Waldmann, H.-D. Arndt, "Synthesis and structure-activity correlation of a brunsvicamide-inspired compound collection", ChemBioChem 2009, 10, 1153-1162.

P. Loos, M. Riedrich, H.-D. Arndt, "Aza-Wittig access to chiral imidazol(in)es", Chem. Commun. 2009, 1900-1902 ("Highlight" in: Synfacts 2009, 7, 728).

R. Tannert, T.-S. Hu, H.-D. Arndt, H. Waldmann, "Solid-phase based total synthesis of jasplakinolide by ring-closing metathesis", Chem. Commun. 2009, 1493-1495.

B. Kilitoglu, H.-D. Arndt, "Scope of Tyrosine O-Arylations with Boronic Acids: Optimized Synthesis of an Orthogonally Protected Isodityrosine", Synlett 2009, 720-723.

S. Schoof, S. Baumann, B. Ellinger, H.-D. Arndt, "A fluorescent probe for the 70S-ribosomal GTPase-associated center", ChemBioChem 2009, 10, 242-245.


H. Waldmann, Y.-P. He, H. Tan, L. Arve, H.-D. Arndt, "Total synthesis of biphenomycin B", Chem. Commun. 2008, 5562-5564. 

J.-Y. Lu, J. Keith, W.-Z. Shen, M. Schürmann, H. Preut, T. Jacob, H.-D. Arndt, "Regioselective de-novo synthesis of cyanohydroxy­pyridines with a concerted mechanism", J. Am. Chem. Soc. 2008, 130, 13219-13221. 

N. Bisek, S. Wetzel, H.-D. Arndt, H. Waldmann, "Synthesis and conformational analysis of stevastelin C3 analogs and their activity against the dual-specific phosphatase VHR", Chem. Eur. J. 2008, 14, 8847-8860. 

H. Waldmann, T.-S. Hu, S. Renner, S. Menninger, R. Tannert, T. Oda, H.-D. Arndt, "Total synthesis of chondramide C and its binding mode to F-actin", Angew. Chem. 2008, 120, 6573-6577; Angew. Chem. Int. Ed. 2008, 47, 6473-6477.

S. Baumann, S. Schoof, S. D. Harkal, H.-D. Arndt, "Mapping the binding site of thiopeptide antibiotics by proximity induced covalent capture (PICC)", J. Am. Chem. Soc. 2008, 130, 5664-5666.

T. Walther, H.-D. Arndt, H. Waldmann, "Solid-support based total synthesis and stereochemical correction of brunsvicamide A", Org. Lett. 2008, 10, 3199-3202. 

H.-D. Arndt, M. Riedrich, "Synthesis of marine alkaloids from the oroidin family", Angew. Chem. 2008, 120, 4864-4867; Angew. Chem. Int. Ed. 2008, 47, 4785-4788.

J.-Y. Lu, W.-Z. Shen, H. Preut, H.-D. Arndt, "(Z)-Methyl-2-(methoxyimino)-3-oxo-butyrate", Acta. Cryst. E 2008, 64, o602.


T.-S. Hu, R. Tannert, H.-D. Arndt, H. Waldmann, "Solid-phase based synthesis of jaspla­kinolide analogs by intramolecular azide/alkyne cycloadditions", Chem. Commun. 2007, 3942-3944.

R. Tannert, M. Schürmann, H. Preut, H.-D. Arndt, H. Waldmann, "(S)-3-((R)-2,4-dimethylpent-4-enoyl)-4-isopropyl-5,5-diphenyloxazolidin-2-one", Acta. Cryst. E 2007, 63, o4381.

H.-D. Arndt, S. Schoof, "Polyamide- and RNA-based activators in living cells: A major step towards controlling gene expression", ChemBioChem 2007, 8, 1095-1098.

J.-Y. Lu, H.-D. Arndt, "Hetero-Diels-Alder synthesis of 3-hydroxypyridines: Access to the nosiheptide core", J. Org. Chem. 2007, 72, 4205-4212.

M. Riedrich, S. D. Harkal, H.-D. Arndt, "Peptide-embedded heterocycles by mild single- and multiple aza-Wittig ring closures", Angew. Chem. 2007, 119, 2755-2758; Angew. Chem. Int. Ed. 2007, 46, 2701-2703.

R. L. Stafford, H.-D. Arndt, M. Brezinski, A. Ansari, P. B. Dervan, "Minimization of a DNA-protein dimerizer", J. Am. Chem. Soc. 2007, 129, 2660-2668. 

R. Wesolowski, A. Sommer, H.-D. Arndt, U. Koert, P. Reiß, S. Wimmers, O. Strauss, "Functional studies on synthetic gramicidin-hybrid ion channels in cells", ChemBioChem 2007, 8, 513-520.


H.-D. Arndt, "Small molecule modulators of transcription", Angew. Chem. 2006, 118, 4664-4673; Angew. Chem. Int. Ed. 2006, 45, 4552-4560.

Before 2006

K. E. Hauschild, R. E. Metzler, H.-D. Arndt, R. Moretti, M. Raffaelle, P. B. Dervan, A. Z. Ansari, "Temperature-sensitive protein-DNA dimerizers", Proc. Natl. Acad. Sci. USA 2005, 102, 5008-5013. 

Y. Kwon, H.-D. Arndt, Q. Mao, Y. Choi, Y. Kawazoe, P. B. Dervan, M. Uesugi, "A small molecule transcription factor mimic", J. Am. Chem. Soc. 2004, 126, 15940-15941.

H.-D. Arndt, B. Ziemer, U. Koert, "On the folding propensity of cyclohexylether-δ-peptides", Org. Lett. 2004, 6, 3269-3271. 

H.-D. Arndt, R. Welz, S. Müller, B. Ziemer, U. Koert, "Stereoselective synthesis of trans-threo-trans oligo-pyrrolidines: Potential RNA cleavage agents", Chem. Eur. J. 2004, 10, 3945-3962.

H.-D. Arndt, K. E. Hauschild, D. P. Sullivan, K. Lake, P. B. Dervan, A. Z. Ansari, "Toward artificial developmental regulators", J. Am. Chem. Soc. 2003, 125, 13322-13323.

H.-D. Arndt, D. Bockelmann, A. Knoll, S. Lamberth, C. Griesinger, U. Koert, "Cation control in functional helical programming: NMR-structures of a d-l-peptide ion channel", Angew. Chem. 2002, 114, 4234-4238; Angew. Chem. Int. Ed. 2002, 41, 4062-4065. 

H.-D. Arndt, A. Vescovi, A. Schrey, J. R. Pfeifer, U. Koert, "Solution phase synthesis and purification of the minigramicidin ion channels and a succinyl-linked gramicidin", Tetrahedron 2002, 58, 2789-2801. 

H.-D. Arndt, A. Knoll, U. Koert, "Cyclohexylether-δ-amino acids: New selec­tivity fil­ters in ion channels", Angew. Chem. 2001, 113, 2137-2140; Angew. Chem. Int. Ed. 2001, 40, 2076-2078.

H.-D. Arndt, A. Knoll, U. Koert, "Synthesis of minigramicidin ion channels and test of their hydrophobic match with the membrane", ChemBioChem 2001, 2, 221-223.

H.-D. Arndt, K. Polborn, U. Koert, "Stereoselective synthesis of a terpyrrolidine unit, a poten­tial building block for anion recognition", Tetrahedron Lett. 1997, 38, 3879-3882.